This study tested a mediation model between depression and neuroticism on 209 college students. Previous research suggests that students who appraise their lives as having no value or worth, which is known as floccinaucinihilipilification (flocci), may be prone to depressive symptoms because of a neurotic disposition. Results found flocci domains targeted at the self and relationships partially mediated the neuroticism-depression relation. Implications and recommendations for professionals are discussed. (Contains 3 tables.)