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ERIC Number: EJ1006139
Record Type: Journal
Publication Date: 2013-Jan
Pages: 6
Abstractor: As Provided
Reference Count: N/A
ISSN: ISSN-1750-9467
Association between Plasma Levels of Transforming Growth Factor-beta1, IL-23 and IL-17 and the Severity of Autism in Egyptian Children
Hashim, Haitham; Abdelrahman, Hadeel; Mohammed, Doaa; Karam, Rehab
Research in Autism Spectrum Disorders, v7 n1 p199-204 Jan 2013
It has been recently shown that dysregulation of transforming growth factor-beta1 (TGF-beta1), IL-23 and IL-17 has been identified as a major factor involved in autoimmune disorders. Based on the increasing evidence of immune dysfunction in autism the aim of this study was to measure serum levels of TGF-beta1, IL-23 and IL-17 in relation to the degree of the severity of autism. Serum TGF-beta1, IL-23 and IL-17 were measured by Enzyme-linked Immunosorbent Assay technique in 50 autistic children aged 6-12 years, in comparison to 50 developmental disabilities and 50 typically developing-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale. We found that TGF-beta1 and IL-23 levels were significantly decreased in the plasma of children with ASD in comparison to control groups (P less than 0.0001 for both) with no significant difference in IL-17 levels. There was no correlation between IL-23 and TGF-beta1 with IL-17 in children with ASD. There was a negative correlation between TGF-beta1, IL-23 and IL-17 with the severity of autism (P less than 0.0001, 0.0001, 0.005 respectively). Our results support the findings that immune dysfunction may occur in some children with autism. (Contains 3 tables.)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: Egypt
Identifiers - Assessments and Surveys: Childhood Autism Rating Scale