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ERIC Number: EJ1006134
Record Type: Journal
Publication Date: 2013-Jan
Pages: 8
Abstractor: As Provided
Reference Count: 0
ISBN: N/A
ISSN: ISSN-1750-9467
L-Carnitine Supplementation Improves the Behavioral Symptoms in Autistic Children
Fahmy, Sarah Farid; El-hamamsy, Manal H.; Zaki, Osama K.; Badary, Osama A.
Research in Autism Spectrum Disorders, v7 n1 p159-166 Jan 2013
L-Carnitine was proposed as a potential treatment for patients diagnosed with autism to ameliorate the behavioral symptoms associated with the disease. Thirty children diagnosed with autism were randomly assigned to receive (100 mg/kg bodyweight/day) of liquid L-carnitine (n = 16) or placebo (n = 14) for 6 months. Measurements included changes in childhood autism rating scale (CARS) form and free and total carnitine levels using tandem mass spectrometry. Results showed significant improvement in CARS scores (P-groups less than 0.001) and (P-overtime = 0.006), with statistically significant differences in free carnitine levels (P = 0.027) and total carnitine levels (P = 0.036). There was no correlation between baseline free and total carnitine levels with changes in CARS scores from zero to 6 months (r greater than 0.5, P greater than 0.05) and generally L-carnitine therapy was well tolerated. In conclusion, L-carnitine therapy (100 mg/kg bodyweight/day) administered for 6 months significantly improved the autism severity, but subsequent studies are recommended. (Contains 9 tables.)
Elsevier. 3251 Riverport Lane, Maryland Heights, MO 63043. Tel: 800-325-4177; Tel: 314-447-8000; Fax: 314-447-8033; e-mail: JournalCustomerService-usa@elsevier.com; Web site: http://www.elsevier.com
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A