ERIC Number: EJ1005323
Record Type: Journal
Publication Date: 2013-Feb
Abstractor: As Provided
Reference Count: 0
Role of Medial Prefrontal Cortex Narp in the Extinction of Morphine Conditioned Place Preference
Blouin, Ashley M.; Han, Sungho; Pearce, Anne M.; Cheng, KaiLun; Lee, JongAh J.; Johnson, Alexander W.; Wang, Chuansong; During, Matthew J.; Holland, Peter C.; Shaham, Yavin; Baraban, Jay M.; Reti, Irving M.
Learning & Memory, v20 n2 p75-79 Feb 2013
Narp knockout (KO) mice demonstrate an impaired extinction of morphine conditioned place preference (CPP). Because the medial prefrontal cortex (mPFC) has been implicated in extinction learning, we tested whether Narp cells in this region play a role in the extinction of morphine CPP. We found that intracranial injections of adenoassociated virus (AAV) expressing wild-type (WT) Narp into the mPFC of Narp KO mice rescued the extinction and the injection of AAV expressing a dominant negative form of Narp (NarpN) into the mPFC of WT mice impaired the extinction of morphine CPP. These findings suggest that Narp in the mPFC mediates the extinction of morphine CPP.
Descriptors: Brain, Animals, Learning Processes, Narcotics, Conditioning, Preferences, Neurological Organization, Biochemistry
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A