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ERIC Number: EJ1004206
Record Type: Journal
Publication Date: 2013
Pages: 12
Abstractor: As Provided
Reference Count: 40
ISSN: ISSN-0211-2159
Effect of Neonatal Clomipramine Treatment on Consummatory Successive Negative Contrast
Ruetti, Eliana; Burgueno, Adriana L.; Justel, Nadia R.; Pirola, Carlos J.; Mustaca, Alba E.
Psicologica: International Journal of Methodology and Experimental Psychology, v34 n1 p25-36 2013
Neonatal administration of clomipramine (CLI) produces physiological, neuroendocrinal and behavioral abnormalities in rats when they reach adulthood, which are similar to those observed in animal models of depression. In consummatory successive negative contrast (cSNC), rats that have had experience drinking 32% sucrose solution drink significantly less 4% sucrose solution than rats that have drunk only 4% solution. It triggers an aversive-emotional reaction similar to fear or anxiety. We studied whether neonatal treatment with CLI alters the cSNC's response in adult rats. The findings of the present work suggest that the neonatal treatment with an antidepressive could generate an increase tolerance to frustration in adult animals. CLI rats showed a faster recovery from the cSNC than control animals, which may be explained by an alteration of the Hypothalamic-Pituitary-Adrenal axis (HPA), a serotonergic system deficit, a low expectative formation during pre-shift phase, or a combination of all these factors. (Contains 1 figure.)
University of Valencia. Dept. Metodologia, Facultad de Psicologia, Avda. Blasco Ibanez 21, 46010 Valencia, Spain. Tel: +34-96-386-4100; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A