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ERIC Number: EJ1002587
Record Type: Journal
Publication Date: 2012-Aug
Pages: 3
Abstractor: As Provided
Reference Count: 11
ISSN: ISSN-0021-9584
An Introduction to Drug Discovery by Probing Protein-Substrate Interactions Using Saturation Transfer Difference-Nuclear Magnetic Resonance (STD-NMR)
Guegan, Jean-Paul; Daniellou, Richard
Journal of Chemical Education, v89 n8 p1071-1073 Aug 2012
NMR spectroscopy is a powerful tool for characterizing and identifying molecules and nowadays is even used to characterize complex systems in biology. In the experiment presented here, students learned how to apply this modern technique to probe interactions between small molecules and proteins. With the use of simple organic synthesis, students prepared different analogues of the well-known anxiolytic drug, nitrazepam. This study constituted the students' first approach into the drug-discovery field and encouraged the students to think about how to improve the design of drugs in a rational way. (Contains 3 figures.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A