ERIC Number: EJ1000580
Record Type: Journal
Publication Date: 2013-May
Abstractor: As Provided
Reference Count: 78
Autism Traits in Individuals with Agenesis of the Corpus Callosum
Lau, Yolanda C.; Hinkley, Leighton B. N.; Bukshpun, Polina; Strominger, Zoe A.; Wakahiro, Mari L. J.; Baron-Cohen, Simon; Allison, Carrie; Auyeung, Bonnie; Jeremy, Rita J.; Nagarajan, Srikantan S.; Sherr, Elliott H.; Marco, Elysa J.
Journal of Autism and Developmental Disorders, v43 n5 p1106-1118 May 2013
Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ's imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well.
Descriptors: Autism, Brain, Neurological Impairments, Anatomy, Screening Tests, Correlation, Imagination, Brain Hemisphere Functions
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A