NotesFAQContact Us
Collection
Advanced
Search Tips
Peer reviewed Peer reviewed
Direct linkDirect link
ERIC Number: EJ1000145
Record Type: Journal
Publication Date: 2012-Dec
Pages: 13
Abstractor: As Provided
Reference Count: 0
ISBN: N/A
ISSN: ISSN-1072-0502
The Episodic Engram Transformed: Time Reduces Retrieval-Related Brain Activity but Correlates It with Memory Accuracy
Furman, Orit; Mendelsohn, Avi; Dudai, Yadin
Learning & Memory, v19 n12 p575-587 Dec 2012
We took snapshots of human brain activity with fMRI during retrieval of realistic episodic memory over several months. Three groups of participants were scanned during a memory test either hours, weeks, or months after viewing a documentary movie. High recognition accuracy after hours decreased after weeks and remained at similar levels after months. In contrast, BOLD activity in a retrieval-related set of brain areas during correctly remembered events was similar after hours and weeks but significantly declined after months. Despite this reduction, BOLD activity in retrieval-related regions was positively correlated with recognition accuracy only after months. Hippocampal engagement during retrieval remained similar over time during recall but decreased in recognition. Our results are in line with the hypothesis that hippocampus subserves retrieval of real-life episodic memory long after encoding, its engagement being dependent on retrieval demands. Furthermore, our findings suggest that over time episodic engrams are transformed into a parsimonious form capable of supporting accurate retrieval of the crux of events, arguably a critical goal of memory, with only minimal network activation.
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A