Despite increasing college enrollment and growing diversity of the college student population, college completion rates are low. Many colleges are exploring ways to leverage technology to improve student retention and increase the educational options for and success of their diverse student bodies. Web-based course or learning management systems and instructional technology centers can be found on almost every U.S. college campus. Colleges are even ranked based on the quality of their technology infrastructure and connectivity. Off campus, technology allowed more than six million college students to take online courses in the 2015-2016 school year. Colleges are using technology to improve the quality of student learning; make active and engaging learning available throughout institutional offerings; and help students become more successful learners. This practice guide, developed by the What Works Clearinghouse™ (WWC) in conjunction with an expert panel, focuses on promising uses of technologies associated with improving postsecondary student learning outcomes. This practice guide makes five evidence-based recommendations around how to use technology to support postsecondary learning. Each recommendation includes examples of technologies and how to implement them, advice on how to overcome potential obstacles, and a summary of the research evidence that supports the recommendation. It provides higher education instructors, instructional designers, administrators, and other staff with specific recommendations for supporting learning through the effective use of technology.