"Fortune" Global 500 Corporations understand that achieving alignment between information and communication technology and enterprise is a major issue. There is much evidence that supports the notion that strategic alignment of information and communication technology (ICT) and enterprise are drivers of economic growth. Addressing information and communication technology and enterprise alignment issues for competitive advantages is critical for "Fortune" Global 500 Corporations. Enterprises are finding ways to benefit from obtaining ICT/enterprise alignment. Prior studies indicate that there is an association between achieving ICT/enterprise alignment and the firm's ability to compete. The purpose of the quantitative method study was to assess the key performance indicator (KPI) technology factors as a potential influencer of ICT/enterprise strategic alignment. In addition, correlate the maturity level associated with each KPI technology factor and ICT/enterprise strategic alignment from ICT and enterprise leaders in "Fortune" Global 500 Corporations. The KPI technology factors consist of consist of financial, reliability, computer-based applications, security, and state-of-the-art information and communication technology. Relating KPI technology factor maturity to ICT/enterprise strategic alignment could contribute to the creation of smarter systems that are more reliable, secure, predictable and cost-effective. This dissertation addresses the lack of ICT/enterprise strategic alignment. The study described in this paper attempted to fill the research void through a quantitative study. First, the author assessed the KPI technology factors as a potential influencer of ICT/enterprise strategic alignment. Second, the author compared the relationship between the maturity level associated with each KPI technology factor and ICT/enterprise strategic alignment. Third, the author performed a series of statistical analyses to examine the relationship between KPI technology factors and ICT/enterprise alignment. In order to leverage the relative importance of KPI technology factors and ICT/enterprise strategic alignment, regression analyses were performed to obtain a further understanding of the relationship. To stay competitive, "Fortune" Global 500 Corporations in energy, hi-tech, health & wellness, and pharmaceutical industries will need to understand ICT/enterprise alignment. Further research involving the relationship between KPI technology factors and ICT/enterprise alignment in other industries should be considered. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]