"AVID" ("Advancement Via Individual Determination") is a college-readiness program whose primary goal is to prepare middle and high school students for enrollment in four-year colleges through increased access to and support in advanced courses. The program, which focuses on underserved, middle-achieving students (defined as students earning B, C, and even D grades), places students in college preparatory classes (e.g., honors and Advancement Placement classes) while providing academic support through a daily elective period and ongoing tutorials. The What Works Clearinghouse (WWC) reviewed 66 studies on "AVID" for adolescent learners. One of these studies meets WWC evidence standards with reservations; the remaining 65 studies do not meet either WWC evidence standards or eligibility screens. Based on one study, the WWC found no discernible effects on comprehension for adolescent learners. The conclusions presented in this report may change as new research emerges. Appendices include: (1) Study characteristics: Rorie, 2007; (2) Outcome measure for the comprehension domain; (3) Summary of study findings included in the rating for the comprehension domain; (4) "AVID (Advancement Via Individual Determination)" rating for the comprehension domain; and (5) Extent of evidence by domain. (Contains 8 footnotes.)