This paper discusses brain-based learning and its relation to classroom instruction. A rapidly growing quantity of research currently exists regarding how the brain perceives, processes, and ultimately learns new information. In order to maximize their teaching efficacy, educators should have a basic understanding of key memory functions in the brain, and how these functions relate to student learning. In this paper, the author surveys current literature to identify foundational instructional strategies that are supported by brain-based research. A Microsoft PowerPoint[R] presentation is included that is intended for use at an in-service training with the goal of providing participants with (1) an overview of research findings with respect to the information processing and memory functions of the brain, and (2) overarching areas of instructional strategies that are supported by current research. The presentation is designed for use by educators and others involved in direct instruction in both primary and secondary education. Two appendixes are included: (1) Pre-Presentation Survey; and (2) Post-Presentation Survey.