Highlights of the 2006 Annual Report include: (1) Program outreach to more than half a million teachers in all 50 states and 50 countries outside of the U.S. via distance-learning tools to provide teachers in some of the poorest and most remote regions of the world with up-to-date materials and training; (2) Advisors to the board of the National Coalition for Literacy, U.S. Secretary of Health and Human Services Advisory Committee, the National High School Center working group that functions as a best-practices clearinghouse for top issues in high school reform, and the American Mathematical Society Committee on Education; (3) Helping the United States prepare the next generation of workers, creators, and leaders in science- and technology-related fields; (4) Health and education research; and (5) Working with governments and agencies around the world to improve nations' health and education: Selected project examples are described, and a financial overview is provided.