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ERIC Number: ED448557
Record Type: Non-Journal
Publication Date: 2000-Aug
Pages: 64
Abstractor: N/A
Reference Count: N/A
Functional Impairment of Bipolar Disorder: A Review of the Literature.
Hanisch, Laura J.
A critical review of neuropsychological results for subjects with bipolar disorder was compared to magnetic resonance imagining (MRI) findings. Studies containing both neuropsychological and MRI outcomes were limited. Therefore, the neuropsychological literature was independently critiqued, then compared to the MRI results from a prior review by Norris, Krishnan, and Ahearn (1997) on structural changes in the brains of patients with bipolar disorder. The reviewed literature appeared to have numerous strengths in research design, but the major limitation was a failure to control statistically for subjects' demographic variables and mediation. The neuropsychological results of persons with bipolar disorder did not reveal generalized deficit but specific functional deficits in memory, learning, and problem solving. These cognitive deficits were well associated with the MRI findings of impaired connections between temporal lobe structures and the prefrontal cortex. Additional analyses of neuropsychological measures and neuroimaging within the same study are strongly suggested. (Contains 32 references.) (Author/CR)
Publication Type: Dissertations/Theses; Information Analyses
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A