This paper reviews variables specific to the Mexican-American culture that might influence work-related behavior and outcomes for youths with disabilities from this population. Areas covered include: parental/family network; cultural view of disability; religious influences; acculturation levels; language issues; education and employment relationships; substance abuse; folk illnesses; and cultural concepts such as "machismo," marianismo," and "familism." The paper then examines the limited (and possibly inconsistent) research on outcomes in supported employment and youth work programs for Latino youths with disabilities. These studies appear to show that these youths do as well as or better than their counterparts from other ethnicities. Recommendations for improvement in service delivery are offered, such as encouraging involvement from local minority business, developing cultural pride and awareness programming, and locating service programs in non-intimidating buildings accessible by public transportation. (Contains 27 references.) (JDD)