This manual was written to help school-based professionals implement school health education programs to prevent the spread of the human immunodeficiency virus (HIV). The manual provides a framework and plan to promote an interdisciplinary approach to HIV education in schools. The manual begins with a review of basic facts about acquired immune deficiency syndrome (AIDS) and the medical spectrum of HIV infection. The next chapter meshes educational and behavioral principles to present a theoretical base for multidisciplinary education. Prevention strategies for school and community are then presented, covering: the specialized roles of school and community personnel; suggested activities for each group; lists of resource organizations, books, videotapes, and other media; and sample program planning and evaluation sheets. Peer education is the focus of the next chapter, with steps in initiating a peer education program and descriptions of model programs. The final chapter presents student skills for prevention of HIV infection, including models and class exercises for teaching decision making, problem solving, refusal, communication, and assertiveness. Appendices provide disease prevention guidelines, curriculum evaluation criteria, library resource lists that cite and annotate 16 books for children and youth and 8 books for adults working with youth, a self-instructional packet (pretest and posttest), position statements, school district policies, and an education programming survey form. (JDD)