A colloquium of 53 Presidential Young Investigators (PYIs), nominated by their institutions and selected by the National Science Foundation, was charged with the task of preparing a report of their vision and recommendations concerning the role of U.S. higher education in the year 2010 and beyond to assure high quality precollege and graduate instruction in engineering, mathematics, and the sciences for everyone. This report, which describes the principal conclusions of the group, includes reports of six individual panels that focus on different aspects of U.S. education. The six panel summaries address and make recommendations on the following issues: attaining and maintaining scientific and technological literacy for all people; encouraging curriculum renewal and the development of new learning environments; incorporating new and evolving technologies into the curriculum; encouraging and preparing students for careers as precollege and college teachers; assuring career participation by all societal groups; and developing young faculty during the critical years to tenure. The colloquium concluded that U.S. higher education must: (1) encourage and reward instructional excellence; (2) increase resources for instructional innovation and curriculum renewal; (3) assume responsibility for public understanding of science and technology; (4) assure career participation in engineering, mathematics, and the sciences by all segments of society; and (5) encourage the development of discovery-oriented learning environments and technology-based instruction. The report includes a list of participants, the charge to the colloquium, the colloquium agenda, and Massachusetts Institute of Technology President Charles M. Vest's colloquium address. (MDH)