The Psychological Screening Inventory (PSI) is useful when there is limited time and resources in mental health settings and counseling centers for the screening of psychological maladjustments. However, few studies have provided norms for Mexican-Americans, and no known study has investigated PSI results as a function of acculturation level. This study investigated differences between Anglo- and Mexican-American college students on the PSI, controlling for the Mexican-Americans' acculturation level as acculturation has been shown to covary with psychosocial variables. Based on data from 105 Anglo-American and 107 Mexican-American college students, it was found that Anglo-American subjects had lower PSI scores on the Alienation and Defensiveness subscales and higher scores on the Social Nonconformity and Expression subscales than did Mexican-American subjects. However, when Anglo-Americans were compared with high acculturated Mexican-Americans, differences only on the Alienation subscale persisted between the two ethnic groups, suggesting acculturation level modifies PSI results. (Author/NB)