This curriculum guide for high-school students presents in-depth coverage of the full range of content related to drugs, including tobacco, alcohol, marijuana, cocaine, narcotics, and hallucinogens. It is part of a series designed to provide educators with the curricular tools necessary to challenge students to take personal responsibility for their health. In addition to the abundance of subject matter content, this 11-lesson curriculum unit involves students in activities that enhance decision-making, problem-solving, and coping skills and helps them develop effective personnal strategies for resisting drug use. The well-developed lessons are designed to give teachers the flexibility to choose, modify, and combine the appropriate content for students. This guide fits within a comprehensive health education program; provides extensive content on commonly abused drugs; explores the legal issues involved in drug use; examines the personal and social costs of drug use; stimulates critical thinking and motivates high school students toward health behavior; and identifies community and school resources that provide counseling, rehabilitation and treatment services for drug users. The lessons include the objective; class time required; a brief overview of the topic; instructional strategies; teacher materials and preparation; procedures; key points; and evaluation materials. A separately bound student workbook contains identical exercises and activities for students as those found in the teacher's guide. (ABL)