Reported are preliminary data from a study of the relationship of three family systems dimensions to three measures of adolescent health extracted from the RAND Health Assessment Questionnaire: the Health Index, General Well-Being, and Symptom Checklist. Three hypotheses were tested: (1) perceived family organization, perceived family privacy, and family problem solving ability should differentially predict three health scores; (2) the relationships between family and health variables would be different in high and low stress families; and (3) for adolescents, each sex would affect such relationships differently. Participants were 175 mainly middle-class families with two adults who cohabited for at least 3 years, had at least one adolescent between 14 and 18 years of age at home, and considered themselves of Anglo or Hispanic heritage. With respect to Hypothesis I, all three family scores showed relationships with adolescent health, with that of perceived family organization displaying the most consistent associations. With respect to Hypotheses II and III, both gender and perceived stress interacted selectively with family-health outcome relationships. It is concluded that the data demonstrate the complex relationships between family and health scores in non-referred samples, and that, because self-report instruments are used widely in family and health studies, researchers must be aware of the differential impact of parental perceptions on offspring. (RH)