This study examines whether male and female teachers differ in: (1) their background or training for instructional uses of microcomputers, and (2) their uses of microcomputers to teach mathematics and science. Research carried out in 60 classrooms in 49 schools in 25 California school districts provided data on district and school microcomputer policies; classroom contexts; and teachers' characteristics, instructional decisions, and practices. Analyses of these data indicated that district and school characteristics and classroom organization and composition did not differ, by and large, among male and female teachers. Furthermore, gender was unrelated to teachers' subject matter and computer knowledge, patterns of microcomputer-based instruction, and instructional decisions and practices. Both female and male teachers provide leadership in the microcomputer movement, have the relevant training and experience that contributes to microcomputer use, use microcomputers for instruction in a variety of ways, and present equally viable role models. (Author/DJR)