This study attempted to determine if test anxiety is manifested in pre-medical students as a result of the Medical College Admission Test (MCAT) and if Beta-endorphin similarly responds to that type of situational stress. Seventeen participants completed the Test Anxiety Inventory (TAI) by Spielberger et al. (1980) and donated 30 ml of blood for Beta-endorphin analysis two days prior to the MCAT and also three days after the test. Student grade point average (GPA) and number of science courses were other variables analyzed. Results indicated that TAI were more elevated pre-MCAT and Beta-endorphin was higher after the examination. Total TAI was significantly inversely related to GPA and there were positive correlations between GPA and MCAT scores. Regression results indicated that select items from TAI, GPA, and Beta-endorphin could be used to predict performance on particular MCAT subsets and that MCAT scores were influenced by test anxiety. Appendices include copies of the TAI, procedures used in processing blood samples for Beta-endorphin, and complete correlation matrices. A 14-page bibliography is included. (ML)