This annotated bibliography covers 170 selected journal articles, books, federal and state government publications, and Educational Resources Information Center (ERIC) documents containing information about the mission, function, and organization of regional educational laboratories or relating to socioeconomic and educational situations in the Appalachian states of Kentucky, Tennessee, Virginia, and West Virginia. The items reflect regional concerns such as educational disadvantagement, nontraditional education, educational improvement, student assessment/evaluation, special education, staff development, multicultural education, rural and small schools, teacher evaluation, teaching techniques, and vocational education. Dates for the entries range from 1962 to 1984, with most occurring during the 1980s. Information was compiled from these items during research for a proposal for a regional educational laboratory serving the Appalachian region. A subject index is included. (LFL)