The paper examines the way preschool children with handicaps interact with and make their response to computer programs, suggesting that the most important factor ensuring successful computer use is finding the most appropriate method of computer access. Difficulties with software programs are noted, including problems with scanning. It is suggested that some children do not possess the required ability to make one-to-one correspondence. In addition, the variety of software programs call for generalization, a skill lacking in many young handicapped children. Difficulties in hardware configurations are also reviewed. Possible adaptations, such as keyboard overlays and expanded keyboards, are considered. Adaptations to paddles and joysticks are described. The potential use of touch screens as response modes is emphasized, as in the need for determining a child's ability to access the computer system. (CL)