This project sought to determine the efficacy of the recently published Centers for Disease Control (CDC) sponsored sexually transmitted diseases (STD) curriculum, "STD: A Guide for Today's Young Adults." Six school districts (rural, suburban and urban) with a participating population of 1,114 students, cooperated with the study. One group of students received the CDC curriculum, one control group received the school's present STD unit, another control group received no STD instruction. Attitudes and knowledge were chosen to be the dependent variables assessed in the project. The treatment length was five class sessions or about 250 minutes. Findings, based on pre- and post-tests and delayed tests, indicated: (1) in general, the CDC sponsored STD curriculum was effective in changing students' STD-related attitudes; (2) the CDC curriculum increased most students' STD-related knowledge; (3) the CDC curriculum was more effective in changing belief and attitude than "intention to act"; (4) the CDC curriculum had less impact on the rural school than the urban and suburban schools; (5) the CDC curriculum was effective with both males and females; (6) the CDC curriculum was more effective than the schools' present STD education; and (7) participants viewed the CDC curriculum positively. The report recommends that the curriculum should be adopted by secondary schools, that it should be taught more than once in the early, middle, and upper secondary school grades, and that the STD scales, particularly the attitude scale (appended to this report), should be used for future research. (JD)