The materials in this guide were designed to help teachers and other adults maximize the learning experiences and other educational events scheduled on space shuttle Mission 51-L. They include: (1) a description of the live lessons to be conducted by Christa McAuliffe; (2) teaching-related events of Mission 51-L; (3) a list of key mission-related terms; (4) pre-viewing activities; and (5) teaching activities. These activities focus on living in space (the shuttle's size, orbital human factors, health and survival, and space stations), working and studying in space (diversity of jobs, benefits and costs, and scientific study), and recording the space experience (creative expression, forms of communication, and space laws and decision). Each activity includes a statement of the concept involved, a list of objectives, and suggested instructional strategies. Lists of resources and National Aeronautics and Space Administration (NASA) Teacher Resource Centers are included. Also included is background information on the ML-5 mission and Teacher in Space Project. (JN)