The purpose of this document is to identify potentially hazardous substances that may be in use in many school laboratories and to provide an inventory of these substances so that science teachers may take the initiative in providing for the proper storage, handling, use, and if warranted, removal of hazardous materials. The document consists of 11 sections: (1) a discussion of a total science safety program; (2) limitations of the guide; (3) instructions for use of health and safety tables; (4) health and safety tables on explosives, toxic substances, substances identified as corrosive/irritating, and substances identified as known or probable human and animal carcinogens; (5) a list of safety recommendations; (6) information on chemical and biological storage rooms and suggested chemical storage patterns; (7) a list of chemicals (in tabular format), which indicates the storage and use hazards for each chemical; (8) recommendations for textbook publishers and science supply companies; (9) a list of organizations to help science teachers deal with chemicals in the school laboratory; (10) a bibliography; and (11) a form used to evaluate the document. (JN)