A brief review of the characteristics of computer assisted instruction and the attributes of audiovisual media introduces this report on a project designed to improve the effectiveness of computer assisted learning through the incorporation of audiovisual materials. A discussion of the implications of research findings on the design and layout of print and the design and utilization of media for learning considers such topics as screen layout, use of media, still pictures, motion pictures, audio, feedback, scoring, and future developments in delivery systems and courseware. The remainder of the report provides detailed information on the computer hardware and random-access audiovisual devices used; the design and development of the computer program, including various subroutines and programming considerations; and detailed information on the various interfaces used. These include interfaces for the Revox Microfiche System with the DEC20, Cromemco System 3, Compucolor II, and Commodore PET; the SONY RX-353 with the Cromemco System 3, Revox Microfiche, Revox Audio, and Apple II; the Acorn Encoder with the Cromemco SDI; and the video switching interface. Diagrams are appended, as well as programs written in BASIC for a 9-part DNA replication. References are provided at the end of each of the introductory chapters. (LMM)