Proposed is a comprehensive instructional design model which (1) suggests a systems-based approach to preparing, implementing, and evaluating instruction at the program syllabus, course syllabus, and instructional unit levels; (2) subsumes those various dimensions of a mastery learning strategy which encompass preconditions, operating procedures, and anticipated consequence; (3) relates the generic activities of instructional design to those essential elements comprising a mastery learning strategy; (4) provides a broad-based context for interpreting completed and on-going research and development efforts in mastery learning; and (5) represents a multidimensional framework for guiding future basic and applied research as well as the subsequent development efforts in mastery learning. Areas of congruence between generic activities in instructional design and essential components in a mastery learning strategy, as well as additional activities mandated by any comprehensive instructional design effort, have provided the basis for identifying possible variables of an independent, moderator, dependent, and intervening nature which might be considered in future mastery learning research and development endeavors. (Author/PN)