This guide is designed for the college instructor who plans to use some of the 12 units of the Mathematics-Methods Program. The program is based on three assumptions about the teaching and learning of mathematics: (1) Mathematics content and methods should be combined in the training of prospective elementary school teachers; (2) Mathematics should be learned in a laboratory setting; and (3) Teachers should be taught as they should teach. These units were written at the Indiana University Mathematics Education Development Center, and they combine the mathematics content and methods learning of college students who are training to be elementary teachers. The units are flexible and can be used in content courses, methods courses, or courses which combine both. In addition to the college classroom component, the program has a coordinated elementary school teaching experience component which is not developed through the units. This guide provides a detailed description of all units and some implementation suggestions. The teaching experience component as implemented at Indiana University is also outlined. (MP)