Alaska has the highest rate in the nation of depression, alcohol and drug abuse, and adolescent suicide. The prevention of depression and suicide is complex because of many impinging variables. Data from a sample of 40 adolescents referred to a residential treatment center in Alaska revealed that a rapid change in life style of the Alaskan natives created a loss of culture and community. A second cause affecting both native and non-native children was the disintegration of the family. The transient population and harsh climate were other major factors in depression. Suicide also had a deeply rooted place in Eskimo culture. Results indicated that natives comprised 55% and caucasians 45% of the referrals, despite the fact that only one in six Alaskans is a native. The findings suggest that therapy should focus on helping adolescents improve their coping strategies and increase their tolerance for discomfort and loss. (JAC)