The final report of Specialized Office Three (S-3) of the Wisconsin Research and Development Center for Cognitive Learning describes activities for improving the quality of instruction for children with handicapping conditions, other than the deaf and blind, through media, materials, and educational technology. In Section I, the project background is reviewed; the philosophy, goals, and objectives of the project are considered; and organization of the project is outlined. Explained in Section II are S-3 activities which include entering 14,321 instructional media and materials into the National Instructional Materials Information System; the initiation of a standardized system for locating, assessing, and abstracting materials; and the development of the Materials Accession Process (MAP) for using teacher input to locate materials and media. Among recommendations covered in a final section is the refinement of MAP and its application to all handicap areas. A second volume contains appended materials which include the following: papers on teaching toilet training and related toileting skills to the developmentally delayed child, on a proposed model for adapting "career discoveries" for use with educable mentally handicapped students, on adaptation of the I CAN primary skills materials for use with severely emotionally impaired/autistic children (5 to 7 years old), on development of a prototype eye teaching system with communication aides for non-vocal severely handicapped children, and on a field test of toilet training with the developmentally delayed child; a material descriptor checklist; and a list of Center products. (SBH)