ERIC Number: ED106690
Record Type: RIE
Publication Date: 1974
Reference Count: 0
Schizophrenics for Whom Phenothiazines May Be Contraindicated or Unnecessary.
Rappaport, Maurice; And Others
In this study of young male schizophrenic patients who reported they were not taking antipsychotic medication at follow-up, those treated with placebos in contrast to those treated with chlorpromazine while hospitalized showed significantly greater long term clinical improvement, less pathology at follow-up, fewer rehospitalizations and better overall functioning in the community between one and three years after discharge. These individuals, in general, were experiencing an acute psychotic break and their first or second hospitalization upon admission to the study. Between hospital admission and discharge those on chlorpromazine showed greater improvement. A greater proportion of those who were assigned to chlorpromazine while hospitalized, however, showed deterioration after discharge. Factors measured at hospital admission that were related to post-hospital outcome were good premorbid history and paranoid characteristics. One evoked potential criterion, slope, also was found to be related to outcome. Similarities and differences between this and other drug outcome studies were discussed. The study supports previous observations that there is a subgroup of schizophrenics who do well or better long term without the routine or continuous use of antipsychotic medication. This finding underlines the need for more selective utilization of antipsychotic medication. Factors which may have an effect on the successful management of acute schizophrenic patients not on medication are mentioned. (Author)
Publication Type: Reports - Research
Education Level: N/A
Sponsor: California State Dept. of Mental Hygiene, Sacramento.; Agnews State Hospital, San Jose, CA.; National Inst. of Mental Health (DHEW), Bethesda, MD.
Authoring Institution: N/A