This study estimates the effect of one year of Fusion Reading implementation, a multistrategy intervention, builds on the work of the Strategic Instruction Model's Learning Strategies Curriculum and Xtreme Reading by integrating some of the same strategies (e.g., paraphrasing, visual imagery, and self-questioning for information acquisition; mnemonics for information study; and writing and error monitoring for information expression), focusing on reading, and extending the time frame from 1 to 2 years in duration. Specifically, the study addressed the following: (1) What are the intent-to-treat impacts of the Fusion Reading intervention on the reading outcomes and motivation to read of struggling readers after receipt of 1 year of the intervention?; (2) For which students are the interventions most and least effective?; and (3) In what ways are implementation factors associated with impacts (or lack of impacts) on reading and motivation outcomes? The authors conducted a randomized controlled trial to estimate the effect of Fusion Reading on struggling readers in grades 6 through 10. Students in the intervention condition received the Fusion Reading intervention as a supplemental reading intervention in the 2010-11 school year, whereas students in the control condition engaged in nonliteracy, "business-as-usual" activities. After one year of implementation of a two year intervention, the authors learned that when vocabulary, paraphrasing and word study strategies are explicitly taught by following a specific instructional routine supported by motivation strategies (e.g., setting goals and reading text relevant for the age group), word reading outcomes will significantly improve compared to control middle and high school students. Future research is needed to fully understand whether the intended two year intervention will improve struggling adolescent's reading comprehension outcomes. Appended are: (1) References; and (2) Tables and Figures. (Contains 2 figures and 5 tables.)