The study aimed to investigate the effectiveness of training programme based on Information Processing through Brain Dominance to enhance Self-Regulation skills and its effect on Reading Comprehension among the sample of preparatory school pupils with English learning disabilities. The sample of the study consisted of (40) pupils with English learning disabilities. The pupils divided into two groups; the experimental (20) pupils and the control group was (20) pupils. A pre and post-test design used for both groups. Author used alert cognitive style scale by Loren Crane 1989, Raven's progressive matrices, Self-Regulation skills scale, reading comprehension test designed by author. The findings showed that there were significant differences in self-regulation skills and reading comprehension favor to the experimental group. The results also showed that there were no significant differences in self-regulation and reading comprehension for follow up evaluation