This report presents an analysis of research on the state of transition, post-secondary education, and employment outcomes for youth and young adults with disabilities over the past 25 years. It identifies what has worked in the areas of transition planning, services, and supports. It also considers what should work in light of unmet needs and unserved populations, focusing on the Individuals with Disabilities Education Act, the Youth Opportunity Movement, Youth Councils and One-Stop Centers under the Workforce Investment Act. Also discussed are the Presidential Task Force on Employment of Adults with Disabilities, the Ticket to Work and Work Incentives Improvement Act, and demonstration projects in special education. Recommendations are offered for the nation (eight recommendations), state and local communities (nine recommendations), and the disability community (three recommendations). Major recommendations to the President and U.S. Congress address the following areas: (1) timely reports by agencies on compliance; (2) redesign of programs that are not producing results; (3) cooperation of the Department of Education and Social Security Administration on eligibility and incentives for greater self-sufficiency; (4) development of data and information-sharing across agencies regarding program implementation; (5) diffusion of knowledge about what works; and (6) specific inclusion of individuals with disabilities in federal programs. (DB)