The past several decades have been times of widespread change in world economies. The 21st century has witnessed scientific technological innovations that have had an impact on almost every sector of our social institutions and the way we do things. To succeed in these changing economies and secure meaningful employment, STEM literacy and education is viewed as a priority. This essay reviews STEM initiatives and curriculums that support integration of Science, Technology, Mathematics and Engineering in Career and Technical Education (CTE) curriculum. A variety of open course software that can be directed to address different aspects of enriching STEM activities in CTE curricular subjects is presented. (Contains 2 figures.)