The University of Wisconsin Learning Innovations Center's instructional design model for World Wide Web delivered courses incorporates a range of collaborative discussions and interactive experiences for the learner. In addition, these courses capitalize on the multimedia learning environment that the web offers to accommodate many kinds of learning styles. This paper provides an overview that highlights the translation of the model into specific online learning activities in the development of a 15-week professional nursing course. Weekly learning activities to enhance student motivation and perception were structured along the following guidelines: (1) build up user confidence with technology; (2) build in the instructor's presence and personality; (3) provide a clear set of learning activities; (4) build on personal and professional experiences of participants; (5) relate content to real situations using case studies and simulation; and (6) build in collaboration and facilitated team projects. Application of these guidelines is discussed. The paper also addresses evaluating the results of the application of the design guidelines by assessing educational effectiveness at the student and instructor levels. (DLS)