Screen designers for computer-mediated instruction (CMI) products must consider the motivational appeal of their designs. Although learners may be motivated to use CMI programs initially because of their novelty, this effect wears off and the instruction must stand on its own. Instructional screens must provide effective and efficient instruction, appropriate navigational tools, and aesthetics. This paper represents a compilation of screen design guidelines from over 90 sources. Guidelines were proposed in whole or in part on the basis of their contribution to motivational appeal. Two primary types of guidelines were discovered--those aimed at enhancing motivation, "expansive," and those aimed at preventing loss of motivation, "restrictive." The paper assesses typography, graphical images, color, animation, and audio, and proposes a framework that CMI designers can use to apply the two types of guidelines and arrive at more effective, efficient, and appealing screen design. (Contains 91 references.) (Author/SWC)