Research on subjective wellbeing includes studies of both domain-related and global distress. The mental health literature, though, focuses almost exclusively on global distress. This seems to be partly due to a common belief that psychological distress, and the moods that comprise distress, necessarily lack referential content. However, if that were the case it would make little sense for any study to ever focus on domain-related distress. The research presented in this report clarifies the relation between global and domain-related distress. We compare confirmatory factor analytic models of the joint relationship among symptoms of global distress with affective symptoms of distress about work, home, and physical appearance. Data are from a general population telephone survey. In the best-fitting models domain-related distress and global psychological distress are related but distinct latent variables. We discuss the theoretical and methodological implications of the models, and model choice.