Health professionals frequently do not possess the necessary information-seeking abilities to conduct an effective search in databases and Internet sources. Reference librarians may teach health professionals these information and technology skills through the Big6 information literacy model (Big6). This article aims to address this issue. It also exposes the possibilities of applying the Big6 model in health sciences libraries and other informational contexts, based on several instances of successful integration of this model into information literacy programs in health sciences environments as well as several instances of using the model for solving diverse information problems within this context. This model promises to be practical for reference librarians and information professionals who are interested in a different approach to instructional and information literacy work in health sciences libraries, thus the paper suggests to take a closer look at Big6.