This study evaluated the effectiveness of comprehension training embedded in a program that taught science content to 2nd graders. The program included instruction about the structure of compare-contrast expository text, emphasizing clue words, generic questions, graphic organizers, and the close analysis of well-structured text exemplars. This program was compared with a program that focused on the science content but included no compare-contrast training as well as with a no-instruction control. Regular classroom teachers (14 from 4 schools), randomly assigned to treatment, provided the instruction; 215 students (7-8 years old) participated. The study replicated acquisition and transfer effects found in an earlier study, that is, transfer to compare-contrast text with content related and unrelated to the instructional content (with no loss in the amount of science content acquired). The program also led to better performance on written and oral response measures and on 1 of the 2 measures involving authentic (less well-structured) compare-contrast text. These findings support and extend previous findings that explicit instruction in comprehension is effective as early as the primary-grade level. (Contains 6 tables, 1 figure, and 1 footnote.)