Background: Despite the distinctive physical, cognitive, personality and behavioural characteristics associated with Williams syndrome, few studies to date have examined parental experiences of raising a child with this genetic syndrome. Methods: This explorative pilot study employed predominantly qualitative methodologies via face-to-face semi-structured interviews with parents. Results: Participants' responses indicated a variety of daily challenges faced by parents of a person with Williams syndrome. Parents also noted challenges unique to this aetiological group that were derived from the oversensitive and highly empathetic nature of the person with Williams syndrome. Parental perceptions relating to the positive impact that a person with Williams syndrome can have on the family were also reported. Discussion: While some of the findings regarding the daily challenges faced by families with a person with WS appear to be similar to the experiences of families who have children with other genetic syndromes and developmental disabilities, the findings indicate that certain daily challenges may also be unique to parents of this aetiological group. In addition, the present study makes a valuable contribution to the research literature focusing on the positive aspects of raising a child with a disability. Future theoretical and practical applications of the present study are also suggested.