Where you find distressed neighborhoods, you will also find poorly performing public schools. Yet many contemporary school reform efforts ignore neighborhood-level factors that undeniably impact school performance. The purpose of this study is to use a case study approach with social institutional and urban school reform regime frameworks to demonstrate why school reform and the re-creation and redevelopment of distressed neighborhoods should occur simultaneously. At the same time, researchers will examine the role of higher education in catalyzing partnerships with so-called anchor institutions for the explicit purposes of simultaneously improving neighborhoods and reforming schools. By focusing on a federal Choice neighborhood initiative, the study will not only make the case for connecting school reform and neighborhood development but also present a model that demonstrates how this can happen. The study will also make a strong case for the university's unique role in fostering neo-collaborative structures fit to take on wicked problems of neighborhood distress and urban decline.