The purpose of this research study is to investigate the effect of the 5E-learning model supported with WebQuest media on the achievement and satisfaction of students. Therefore, two groups of students were compared in an experimental research design model. The experimental group was exposed to the 5E-learning model supported with WebQuest media; the control group was exposed to only the 5E-learning model in the classroom. The study was carried out with 104 students at a K12 school in Turkey, in the 2010-2011 spring semester. Of 104 students, 52 were randomly assigned to the experimental and control groups, respectively. The data were collected through an achievement test and a scale. The findings indicated that the 5E-learning model supported with WebQuest media promotes students' learning and the instruction provided through this environment satisfies students, particularly the female ones. It is suggested that, considering the significant difference between the groups of students in terms of their achievement and the positive effect of WebQuest on students' learning, WebQuest may be embedded into teaching. High satisfaction levels of the students with the WebQuest intervention is expected to contribute to students' motivation, which also positively affects their learning.