The experience of living with multiple sclerosis (MS) can have a profound effect on employment. The impact of MS is a complex interaction of personal, medical, functional, financial, and psychosocial variables that ultimately results in up to 80% of persons with MS leaving their jobs within 10 years of their diagnosis. The aim of this study was to investigate whether the employment status of applicants with MS who were seeking services from state vocational rehabilitation (VR) agencies could be classified based on the type of services provided. A quantitative descriptive research design employing discriminant analysis (DA) was used to determine differential services received by employed and unemployed applicants with MS. Findings indicate that persons with MS who were employed at application were more likely to receive services geared toward career stabilization (i.e., assistive technology/accommodation services, counseling and guidance, and cognitive retraining-type rehabilitative services). Conversely, the unemployed applicant group had a higher propensity to receive services focused on job placement (i.e., job readiness, job seeking, and job placement services). Although a disparity persisted between the average worker in the United States and the outcomes achieved by VR service recipients regarding weekly wages and hours, services provided by the state-federal VR program reduce this disparity. In addition, the return on investment (ROI) associated with providing services to persons with MS was calculated as providing an $8 return for every dollar spent. Persons with MS employed at application had an ROI of more than $10 for every dollar spent. Implications for persons with MS, rehabilitation counselors, health care professionals, and policymakers are provided.