The recent emergence of assistive technology encourages researchers and educators to explore its possible benefits for students who lack the reading and writing skills necessary for success in higher education. Assistive technologies include text-to-speech software, word-processing programs, voice-recognition software, and software for organizing ideas. While these technologies are relatively new, they hold the promise of bridging the gap between a student's needs and abilities. This article explains how a combination of sound instructional strategies for improving reading comprehension, accuracy, fluency, and writing with assistive technology helped students make gains beyond what they had achieved previously. Two case studies illustrate the efficacy of this approach in preparing such students for postsecondary education.