The roles of visual sonority and handshape markedness in sign language acquisition and production were investigated. In Experiment 1, learners were taught sign-nonobject correspondences that varied in sign movement sonority and handshape markedness. Results from a sign-picture matching task revealed that high sonority signs were more accurately matched, especially when the sign contained a marked handshape. In Experiment 2, learners produced these familiar signs in addition to novel signs, which differed based on sonority and markedness. Results from a key-release reaction time reproduction task showed that learners tended to produce high sonority signs much more quickly than low sonority signs, especially when the sign contained an unmarked handshape. This effect was only present in familiar signs. Sign production accuracy rates revealed that high sonority signs were more accurate than low sonority signs. Similarly, signs with unmarked handshapes were produced more accurately than those with marked handshapes. Together, results from Experiments 1 and 2 suggested that signs that contain high sonority movements are more easily processed, both perceptually and productively, and handshape markedness plays a differential role in perception and production.