This study examined the role of cognitive (i.e., grit, hope, and academic skepticism) and cultural variables (i.e., generational status, familismo, ethnic identity, and bicultural stress) on academic motivation among 181 Mexican American adolescents. Results indicated that hope, grit, and familismo positively predicted academic motivation. Conversely, academic skepticism and bicultural stress negatively predicted academic motivation. This study demonstrates that culture is important to consider above and beyond cognitive variables. Implications for practice and research are discussed.