Little is known about trauma-related symptoms among runaway adolescents. Precocious departure from familial homes often exposes youth to traumatic victimization. This study examined the extent to which runaway adolescents present trauma symptomotology and assessed factors that predict trauma symptoms. Participants (N = 350) were 12-18 years of age and currently domiciled in youth emergency shelters. Results showed that trauma symptoms were not significantly greater than found among other youth norms. Multiple regression models indicated that being male, experiencing depression, sexual concerns, and problems in family functioning significantly predicted trauma-related symptoms of anxiety, posttraumatic stress, and dissociation. However, lack of peer support, depression, and substance abuse predicted the trauma-related symptom of anger. Findings suggest that effective services target the entire family unit and develop greater cohesion and support within the family. (Contains 5 tables.)